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Notably, the combination of SGLT2i and oral semaglutide was associated with reductions in HbA 1c and weight comparable to the other individual GLP-1RAs

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Leaves (Asnis, Figure 4 Figure 5 In addition, the predicted subcellular localization of GR was analyzed using ProtCompB, SignalP 4.1, and PSORTB v3.0, and no signal peptide or transmembrane region was found, suggesting that it may be cytoplasmic protein, which is consistent with the neutral optimum pH of GR

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